HydRegen Limited sell "Bio2Amine for Mesalazine (mesalamine)"

Mesalazine (mesalamine, 5-aminosalicylic acid) is a pharmaceutical used for ulcerative colitis, Crohn's disease, and inflammatory bowel disease. HydRegen's Bio2Amine technology enables highly selective hydrogenation of 5-nitrosalicylic acid (5-NSA) to 5-aminosalicylic acid without observable intermediates or side products. Bio2Amine is a slot-in biocatalytic alternative to conventional catalysts for nitro-to-amine reduction, eliminating the need for precious metals in hydrogenation. It is a cofactor-free, heterogeneous biocatalyst demonstrated to fully convert nitro groups to amines across more than 50 compounds, with strong tolerance of other functional groups such as unsaturated bonds, halogens, and sulphur.