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RC

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Biografía

I lead the Translational Immuno-Pharmacology research group at the Systems Pharmacology and Pharmacy division of the Leiden Academic Centre for Drug Research, Leiden University, the Netherlands. Translating drug effects from prelinical experimental data to clinical doses and efficacy requires smart data and computational models. Pharmacokinetic-pharmacodynamic models are essential to that objective. With more innovative experimental techniques, we should now add the dynamics of the host, quantifying the complex relationship between disease, drug, and patient. Both to determine the contribution of immunity and inflammation to conventional therapy, and to develop innovative host-directed therapies. I believe that the open questions in medical research can only be answered when state-of-the-art science from all relevant disciplines is integrated; both experimentally and computationally. This is why I see the value in collaborating across disciplines, which I also very much enjoy. I am curiosity driven and like to get to the bottom of open questions and needs, and scientific theories and methods, to learn to speak the language of other scientific or societal partners. Only when speaking the same language, and with proper preparation, a dialogue can be useful and efficient. This means that experiments can be designed with the computational analysis in mind, and subsequent results can be interpreted with the experimentalist's expertise. Talents - Translational pharmacology to predict clinical efficacy from preclinical data - Collaboration, communication, and leadership across computational, clinical, and experimental disciplines - Knowledge integration in translational and clinical pharmacology through data analysis and visualization - Precise and efficient project management - Inclusive mentorship and supervision Skills Systems pharmacology, pharmacometrics, pharmacokinetics-pharmacodynamics, translational pharmacology, data analysis and visualization, drug development, clinical trial analysis, clinical trial design, preclinical experiments, experimental design, infectious diseases, zebrafish biology, analytical chemistry, microbiology, computational bio-imaging, project management, team leadership, presentation and outreach, grant application

Educación

  • Universiteit Leiden
    Título PhD candidate
    Campo de estudio Leiden Academic Centre for Drug Research (LACDR)
    Fecha de inicio 01/2015
    Fecha de fin 01/2019
  • Universiteit Leiden
    Título PhD
    Campo de estudio Leiden Academic Centre for Drug Research (LACDR)
    Fecha de inicio 01/2015
    Fecha de fin 01/2019
  • Universiteit Leiden
    Título MSc
    Campo de estudio Leiden Academic Centre for Drug Research (LACDR)
    Fecha de inicio 01/2013
    Fecha de fin 01/2015
  • Universiteit Leiden
    Título BSc
    Campo de estudio Leiden Academic Centre for Drug Research (LACDR)
    Fecha de inicio 01/2009
    Fecha de fin 01/2013

Experiencia

UO

postdoctoral researcher

University of California San Francisco

01/202201/2023

Bioengineering and Therapeutic Sciences

UU

postdoctoral researcher

Uppsala Universitet

01/202001/2022

Farmakometri, Institutionen för farmaceutisk biovetenskap

UL

postdoctoral researcher

Universiteit Leiden

01/201901/2020

Institute of Biology Leiden (IBL)