(S)-(+)-3-Hydroxytetrahydrofuran

(S)-(+)-3-Hydroxytetrahydrofuran (CAS 86087-23-2) is a key chiral intermediate used in the synthesis of the antiretroviral drug amprenavir, produced via routes such as asymmetric reduction or hydrosilylation of dihydrofuran, asymmetric hydrogenation with intramolecular etherification of 4-chloro-3-oxobutanoate, or enzymatic resolution of the racemic compound. It is manufactured directly by Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. to Chinese Pharmacopoeia (ChP) standards, with samples available, and is distributed to markets across Asia, the Americas, Europe, the Middle East, and Africa.