EC Number: 608-974-4
Chemical Formula: C₇₂H₁₀₄Na₈O₄₈S₈
CAS Number: 343306-79-6
IUPAC Name: octasodium;3-[[(1S,3S,5S,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31S,33S,35S,36S,38S,40S,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-10,15,20,25,30,35,40-heptakis(2-carboxylatoethylsulfanylmethyl)-41,42,43,44,45,46,4
Molecular Weight: 2178
Polymorphic Form: También está disponible un nuevo polimorfo cubierto por la patente propia del proveedor, además de la forma estándar.
Valoración (Assay): Fabricado conforme a un estándar empresarial establecido según ChP/USP/EP, diseñado como un 'sumidero farmacológico' de gamma ciclodextrina para rocuronio y vecuronio, sin los efectos secundarios cardiovasculares relacionados con el sistema colinérgico.

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Descripción adicional:

Neuromuscular blocking (NMB) agents are widely used alongside anesthesia to support tracheal intubation, mechanical ventilation, and surgical access. Sugammadex reverses the effect of the non-depolarizing blockers rocuronium and vecuronium by acting as a selective binding agent for these molecules, avoiding the cardiovascular side effects seen with reversal agents that act directly on the cholinergic system. Its gamma-cyclodextrin core is modified with acidic side chains that create an electrostatic attraction to the blockers' positively charged nitrogen center. These side chains are introduced through a halogenation step followed by nucleophilic substitution, with a final hydrolysis step yielding sugammadex sodium.