New Zealand RS&T Curriculum Vitae Template PART 1 1a. Personal details Full name Title Dr First name Victor Second name(s) Family name Knopov Present position Chief Technology Officer Organisation/Employer South Pacific Sera Ltd Contact Address PO Box 2117 Timaru, 26 Kennel Road New Zealand Post code 7941 Work telephone +64 3 687 4050 Mobile +64 21 467 317 Email [email protected] Personal website (if applicable) 1b. Academic qualifications 1986 - Ph.D., Applied Sciences, University of Saint-Petersburg, Department of Biotechnology, Russia. 1973 - M.Sc., Biochemistry, University of Donetsk, Chemistry Faculty, Ukraine. 1c. Professional positions held Chief Technology Officer (July 2022 – Present), South Pacific Sera Ltd. (Timaru, New Zealand) - Responsible for R&D Operation. Chief Technology Officer (July 2019 – June 2022), COI Pharmaceutical INC.(San Diego, CA) - Responsible for Technical Operations of mAb and liposomal (Ankasa) drug development. Chief Technology Officer (Dec 2016 – Dec 2017) Engene Inc.(Montreal, Canada) – Responsible for oral gene-based therapeutics proprietary gut-targeting Nanoparticles (chitosan derivatives) platform. Executive Vice President, Pharmaceutical Development, (2012 – 2016) Regulus Therapeutics (San Diego, CA) is a biopharmaceutical company focused on the development of targeted RNA-based drugs – Responsible for corporate pharmaceutical development. Director, CMC (2010 - 2012), Nitto Denko Technical Corporation (San Diego, CA) – Responsible for corporate Chemistry, Manufacturing and Control (CMC) of targeted RNA/LNP. Director, Manufacturing (1997 - 2008), Tekmira Pharmaceuticals Corporation (currently Arbutus Biopharma Corp. (NASDAQ: ABUS); formerly Inex Pharmaceuticals Corp.) is a Canadian biopharmaceutical company, developing and commercializing lipid nanoparticles proprietary drug delivery systems - Responsible for manufacturing of RNA/LNP and anticancer sphingosomes. 1d. Present research/professional speciality GENE MODULATION/RNA TARGETED THERAPEUTICS & NANOPARTICLE DRUG DELIVERY SYSTEMS 1e. Total years research experience  25 years 1f. Professional distinctions and memberships (including honours, prizes, scholarships, boards or governance roles, etc) enGene Inc (Montreal, Canada) - Board member 2016-2017 Diversified BioMedical, Washington, USA – Board member 2008-2010 Biotalent Canada – the Canadian government organization for the science of talent podcast - Board member 2008-2010 1g. Total number of peer reviewed publications and patents Journal articles Books, book chapters, books edited Conference proceedings Patents 14 PART 2 2a. Research publications and dissemination Peer-reviewed journal articles Peer reviewed books, book chapters, books edited Refereed conference proceedings Patents 1. SYSTEMS, COMPOSITIONS, AND METHODS FOR FORMULATING NUCLEIC ACID COMPOSITIONS Publication number: 2017048770 A1 Inventors: Priya Karmali, Victor Knopov and Amit Sagi 2. LIPIDS FOR THERAPEUTIC AGENT DELIVERY FORMULATIONS Patent number: 9308267 Inventors: Joseph E. Payne, John A. Gaudette, Zheng Hou, Mohammad Ahmadian, Lei Yu, Victor Knopov, Violetta Akopian, Priya Karmali, Richard P. Witte, Neda Safarzadeh, Wenbin Ying, Jun Zhang 3. CATIONIC LIPIDS FOR THERAPEUTIC AGENT DELIVERY FORMULATIONS Patent number: 9242001 Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Zheng Hou, John A. Gaudette, Violetta Akopian, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C. Nagarajan 4. COMPOSITION FOR REGENERATING NORMAL TISSUE FROM FIBROTIC TISSUE Publication number: 20160015656 Inventors: Yoshiro Niitsu, Akihiro Yoneda, Hirotoshi Ishiwatari, Joseph E Payne, John A Gaudette, Zheng Hou, Victor Knopov, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Yasunobu Tanaka, Violetta Akopian 5. CATIONIC LIPIDS FOR THERAPEUTIC AGENT DELIVERY FORMULATIONS Patent number: 9011903 Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Zheng Hou, John A. Gaudette, Violetta Akopian, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C. Nagarajan 6. SINGLE USE SYSTEM FOR STERILELY PRODUCING LIPID-NUCLEIC ACID PARTICLES Patent number: 8956572 Inventors: Victor Knopov, Richard P. Witte, Priya Karmali, Robin Lee, David Webb 7. RETINOID-LIPOSOMES FOR TREATING FIBROSIS Patent number: 8741867 Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin-Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu 8. RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION Patent number: 8664376 Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Richard P. Witte, Mohammad Ahmadian, Lo