追加説明:
Appearing as a white crystalline powder with a camphor-like odor that readily sublimes, this chlorobutanol hemihydrate dissolves in ethanol, chloroform, ether, or volatile oils but only slightly in water, meeting CP2020, USP43-NF38, EP9.0/10.0, BP2017/2020, and JP17 specifications. Commonly used as a preservative at around 0.5% w/v, it appears in ointments, ophthalmic preparations, and veterinary injections (such as oxytocin, colistin sulfate, chlorogenic acid, cephalexin, and tolfenamic acid), and is especially suited to non-aqueous preparations; it is bacteriostatic (not bactericidal) against Gram-positive and Gram-negative bacteria and some fungi like Candida albicans and Pseudomonas aeruginosa, though its activity drops markedly above pH 5.5.
評価とコメントを残す