Jia-Guo Zhou, MD, PhD Prof. Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University. 74 Zhongshan 2 Rd, Guangzhou, 510080, China. Tel: 86-20-87330554(O). E-mail: [email protected] Education Sept. 1999 - July 2004 PhD Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China Sept. 1989 - July 1994 Bachelor Wannan Medical college, Wuhu, China Working Experience Jan. 2009 –present Professor Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China Jan. 2007 – May. 2008 Postdoc Department of Pharmacology & Physiology, University of Medicine and Dentistry of New Jersey, Newark, USA Jan. 2006 –Dec. 2008 Associate Professor Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China July. 2004-Dec.2005 Lecturer Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China Sept. 1994-Aug. 1999 Assitant Department of Physiology, Wannan Medical college, Wuhu, China Research interests 1. The characteristics and functions of ion channels in cardiovascular system. 2. Interaction between cardiovascular system and kidney. 3. Molecular mechanism of atherogenesis and hypertension. Publications: 1. Liu XY, Zhang FR, Shang JY, Liu YY, Lv XF, Yuan JN, Zhang TT, Li K, Lin XC, Liu X, Lei Q, Fu XD, Zhou JG*, Liang SJ*. Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity. Cell Death Dis. 2018;9(6):610. 2. Mai XY, Shang JY, Liang SJ, Yu BX, Yuan JN, Lin Y, Zhang FR, Liu YY, Lv XF, Li CL, Wang WD*, Zhou JG*. Blockade of Orai1 Store-Operated Calcium Entry Protects Against Renal Fibrosis. J Am Soc Nephrol 2016;27(10):3063-3078 3. Liang SJ, Zeng DY, Mai XY, Shang JY, Wu QQ, Yuan JN, Yu BX, Zhou P, Zhang FR, Liu YY, Lv XF, Liu J, Ou JS, Qian JS*, Zhou JG*. Inhibition of Orai1 Store-operated Calcium Channel Prevents Foam Cell Formation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016; 36(4):618-28. 4. Huang LY, He Q, Liang SJ, Su YX, Xiong LX, Wu QQ, Wu QY, Tao J, Wang JP, Tang YB, Lv XF, Liu J, Guan YY, Pang RP*, Zhou JG*. ClC-3 Chloride Channel/antiporter Defect Contributes to Inflammatory Bowel Disease in Humans and Mice. Gut. 2014;63(10):1587-1595 5. Wang M, Yang H, Zheng LY, Zhang Z, Tang YB, Wang GL, Du YH, Lv XF, Liu J, Zhou JG*, Guan YY*. Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension through promoting basilar smooth muscle cell proliferation. Circulation 2012;125(5): 697-707 6. Yang H, Huang LY, Zeng DY, Huang EW, Liang SJ, Tang YB, Su YX, Tao J, Shang F, Wu QQ, Xiong LX, Lv XF, Liu J, Guan YY, Zhou JG*. Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-κB pathway. Hypertension 2012;60(5):1287-93. 7. Sun HX, Zeng DY, Li RT, Pang RP, Yang H, Hu YL, Zhang Q, Jiang Y, Huang LY, Tang YB, Yan GJ*, Zhou JG*. Essential role of microRNA-155 in regulating endothelium- dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension 2012;60(6):1407-14. 8．Liu YJ, Wang XG, Tang YB, Chen JH, Lv XF, Zhou JG*, Guan YY*. Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. Hypertension. 2010;56(3):445-52. 9. Wu QQ, Liu XY, Xiong LX, Shang JY, Mai XY, Pang RP, Su YX, Yu BX, Yuan JN, Yang Chao, Wang YL, Zhou P, Lv XF, Liu J, Zhou JG*, Liang SJ*. Reduction of Intracellular Chloride Concentration Promotes Foam Cell Formation. Circ J 2016;80(4):1024-33. 10. Hong L, Xie ZZ, Du YH, Tang YB, Tao J, Lv XF, Zhou JG*, Guan YY*. Alteration of volume-regulated chloride channel during macrophage-derived foam cell formation in atherosclerosis. Atherosclerosis 2011; 216(1):59-66.