Maitre-Auxiliaire (Sciences Naturelles, Histoire et Sport

Patrice X. Petit completed his studies at University Pierre et Maris Curie in France and earned a Ph.D. in Biology from the University Denis Diderot in Paris. Early in his career, Patrice X. Petit worked for the French National Research Center (CNRS, since 1979). He is a Cell Biology Research Director at CNRS. After an early career devoted to the physiology of lichenic symbiosis (partner relationship and lectins), Patrice X. Petit specialises in the bionergetics of mitochondria in photosynthetic tissues. He keep in mind all along its work that mitochondria are issued from an early endosymbiotic context. In the 1990’s Patrice X. Petit shifted from plant physiology to mammalian cell biology studies. He specialize early in flow cytometry techniques and developed a fine analysis of isolated mitochondria in flow together with a special dedication to bioenergetic (and also of other organelles like chloroplast, nuclei and also lipidic vesicles (GUVs). Patrice X. Petit was leading the discovery of involvement of mitochondria in apoptosis (mainly centered around a drop in mitochondrial membrane potential and the fact that mitochondrial membrane permeabilization is a concrete step in the process of programmed cell death). At first, he published with B. Mignotte and J.L. Vayssière (1994) in PNAS, the pioneering work highlighting the essential role of mitochondrial potential in the early stages of apoptosis and on is proper name in 1995 in Journal of Cell Biology. He pursued this work afterwards as senior scientist in the Guido’s Kroemer team (Journal of Exp.Med. a and b in 1995). Clearly the change of theme and the meeting with apoptosis specialists (J.L. Vayssière and Bernard Mignotte), allowed him, as a specialist in mitochondrial bioenergetics, to point out the missing link between pro-apototic signalling from the plasma membrane to the executing caspases, i.e. the destabilisation of the mitochondrial compartment in terms of membrane potential, structure and permeability of the outer membrane (PNAS 1994 Vol. 91, pp. 11752-11756, and J. Cell Bio. 1995, 130, 1, 157-167). This work formed the basis for the subsequent discovery of cytochrome c release and its adaptation to APAF-1/caspase-9 as a major pathway for the induction of apoptosis (Li P and X. Wang 1997). Journal reviewer for: Antioxidant, Apoptosis, BBA, Cancer Research, Cellular and Molecular Biology, Cell Death and Diseases, Cell death and Differentiation, Cells, Blood, FASEB Journal, Frontiers in Bioscience-Landmark, International Journal of Molecular Sciences, Journal of Biological Chemistry, Journal of Cell Biology, Journal of Cell Science, Journal of Immunology, JoVE Research, Molecular and Cellular Biology, Molecules, Oncogene, PLoS One, Proceedings of the National Academy of Sciences USA (PNAS), Grant reviewer for: Academy of Sciences of Austria; Agence Nationale de Recherche, France; Agencia Nacional de; Association pour la Recherche sur le Cancer, France; EMBO (European Molecular Biology Organization) Fellowship Program; EMBO Young Investigator Program; European Science Foundation; Fondation pour la Recherche Médicale, France; Institut National de la Santé et de la Recherche Médicale (INSERM), France; Swiss National Science Foundation. Teaching and abroad experiment Academia of Sciences, Beijing (Pékin), China, Autonomous University of Madrid, Spain, Faculty of Sciences; Ecole Supérieure de Physique et de Chimie Industrielle de la Ville de Paris, France; University of Odense, Denmark; University of Innsbruck, Austria, Faculty of Medicine, Austria; University of Lund, Sweden; University of Lyon, Faculty of Medicine, France; University of Lyon, Scientific University, France; Medical School Manchester, Manchester, Max-Planc institut Martinried, München, Germany; England, University of Nice Sophia Antipolis, France; University of Paris VI, Pierre et Maris Curie, Faculty of Sciences, France; University of Paris VII Denis Diderot, Faculty of Medicine, France; University of Paris René Descartes-Necker Hospital, France; University of Paris Sud, Faculty of Sciences, France; University of Stockholm, Arrhenius Laboratoriet, Sweden; University of Strasbourg, France,; University of Umeä, Sweden; University of Valencia, Faculty of Medecine, Spain; University of Vancouver, Vancouver, Canada; University of Versailles-Saint Quentin, Faculty of Sciences, France; University of Whenzhou, China; University of Würzburg, Plant physiology department, Germany; UT SouthWestern, Dallas, Texas, USA. Licenced in History, University Paris Diderot 1979 DIU Maladies rares, University of Strasbourg 2017 Elected member of the Scientific Council of the Institut of Biological Sciences (INSB) of CNRS, 2016 - 2020 ORCID number 0000 - 0002 - 5038 - 9101 Publications : 134 occurences, 12500 citations and h index 43 (mixed sources, Web of Sciences, PubMed, ResearchGate, Google Scolar including the plant research field). lien: https://www.researchgate.net/profile/Patrice-Petit