EDUCATION/TRAINING INSTITUTION DEGREE YEAR(s) FIELD OF STUDY Tongji pharmacy school, Huazhong University of Science and Technology Doctor of Medicine 2014-2017 Pharmacology Hubei University of Chinese Medicine Master of Medicine 2009-2012 Pharmaceutical Analysis Hubei University of Chinese Medicine Bachelor of Science 2005-2009 Pharmacy Positions, Research Experience, Research Grants and Publications: Positions 2022/11 - present, Pharmacists in Charge, Department of Pharmacy, Shanghai Public Health Clinical Center 2017/7 - 2021/10, Pharmacists in Charge, Department of Pharmacy, Renmin Hospital of Wuhan University 2013/5 - 2014/8, Formulation Scientist, QR Pharmaceuticals Corporation 2012/8 - 2013/5, Preformulation Scientist, Asymchem laboratories (Tianjin) Research Experience 1. Pharmacists in Charge, Shanghai Public Health Clinical Center, Fudan University  Clinical comprehensive evaluation of quinolone drugs in the treatment of tuberculosis 2. Pharmacists in Charge, Renmin Hospital of Wuhan University  Proteomics-oriented mechanistic study  Study of the microbial composition changes of the mouse gut via 16S rRNA sequencing after feeding of resistant starch 3. PhD student, Tongji pharmacy school, Huazhong University of Science and Technology, majoring in pharmacology, Supervisor: Prof. Robert Gilbert  Analysis of liver glycogen structure using size exclusion chromatography and fluorescence assisted capillary electrophoresis 4. Formulation Scientist, QR Pharmaceuticals Corporation  Prescription optimization and small-scale verification of granules  Optimization of Tablet Formulation and small-scale verification  Development of methods for liquid chromatography detection of relevant substances  Prescription and process optimization of pellets prepared by extrusion rolling integrated method 5. Preformulation Scientist, Asymchem laboratories  Investigating the number and stability of drug crystal forms(Using X-ray Powder diffractometer, Polarized light microscopy, Thermal Gravimetric Analyzer, and Differential Scanning Calorimeter)  Determination the pKa and LogP of several drugs 6. Postgraduate Student, majoring in Pharmaceutical Analysis, Hubei University of Chinese Medicine, Supervisor: Prof. Xudong Fu  PLGA nanoparticles for the delivery of paclitaxel 7. College student, Hubei University of Chinese Medicine, Instructor: Prof. Hong Wang  Optimization of synthesis process of polyethylene glycol monomethyl ether succinate monoester by orthogonal design Hosting Research Grants 1. The role and mechanism of Akt1 in the treatment of type 2 diabetes mellitus by resistant starch, Medical and Health Science and Technology Innovation Fund Project of Jinshan District, 2023-WS-27, 2023.05-2025.4 2. Clinical comprehensive evaluation of quinolone drugs in the treatment of tuberculosis in the context of mass procurement, Scientific research projects of Shanghai Public Health Clinical Center, KY-GW-2022-39, 2022.01-2023.12 3. The role and mechanism of glycogenin-mediated changes in the structure of liver glycogen in the treatment of type 2 diabetes mellitus by resistant starch, National Natural Science Foundation of China, 81803230, 2019.01-2021.12 4. The role of structural changes of hepatic glycogen in the prevention and treatment of diabetes with resistant starch, Basic scientific research projects of central universities, 2042018kf0143，2018.01—2019.12 5. Mechanism study of hepatic glycogen structure optimization and protection against islet β-cell apoptosis by resistant starch, Guide fund of Renmin Hospital of Wuhan University, RMYD2018M57，2018.1-2019.12 List of publications (first author and corresponding author) 1. Wang Z#, Hu Z#, Deng B, Gilbert RG, Sullivan MA. The effect of high-amylose resistant starch on the glycogen structure of diabetic mice. International Journal of Biological Macromolecules 2022; 200: 124-31. (Co-first author) 2. Li C, Hu Z*. Is liver glycogen fragility a possible drug target for diabetes? Faseb j 2020; 34(1): 3-15. (Corresponding author) 3. Hu Z, Li E, Sullivan MA, et al. Glycogen structure in type 1 diabetic mice: Towards understanding the origin of diabetic glycogen molecular fragility. International Journal of Biological Macromolecules 2019; 128. 4. Hu Z, Deng B, Tan X, et al. Diurnal changes of glycogen molecular structure in healthy and diabetic mice. Carbohydr Polymer 2018; 185: 145-52. 5. Hu Z, Tan X, Deng B, et al. Implications for biological function of lobe dependence of the molecular structure of liver glycogen. European Polymer Journal 2017; 90: 105-13.