I am Fouad H. Darras, a Jordanian medicinal chemist. I got my PhD in Medicinal Chemistry from the department of chemistry and pharmacy at Regensburg University – Germany in April 2014. Title of my thesis: Synthesis and Biological Evaluation of Novel Inhibitors of Cholinesterases for the Treatment of Alzheimer’s disease. I started my PhD in October 2010, in April 2010; I got The German Academic Exchange Service (DAAD) scholarship for three years. In August 2012, my 1st project has been published in ACS Medicinal Chemistry Letters, entitled with: Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer, Fouad H. Darras, Beata Kling, Jörg Heilmann, and Michael Decker*, ACS Med. Chem. Lett. 2012, 3, 914−919. (The manuscript is attached) In December 2013, my 2nd project has been published in ACS Chemical Neuroscience, entitled with: Synthesis, biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChEInhibitors and hH3 Receptor Antagonists, Fouad H. Darras , Steffen Pockes , Guozheng Huang , Sarah Wehle , Andrea Strasser , Hans-Joachim Wittmann , Martin Nimczick , Christoph A. Sotriffer , and Michael Decker*, ACS Chem.Neurosci. 2014, 5 (3), 225-242. (The manuscript is attached) In June 2014, my 3rd project has been accepted for publishing in Bioorganic and Medicinal Chemistry, entitled with: Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase, Fouad H. Darras, Beata Kling, Edgar Sawatzky, Jörg Heilmann and Michael Decker* Bioorg Med.Chem. 2014, 22 (17), 5020-5034.(The manuscript is attached) In the same month my 4th project has been accepted for publishing in Bioorganic and Medicinal Chemistry, entitled with: Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with "inverted" binding mode, Fouad H. Darras, Sarah Wehle, Guozheng Huang, Christoph A. Sotriffer, and Michael Decker* Bioorg Med.Chem. 2014, 22 (17), 4867-4881. (The manuscript is attached) I have also two publications as co-author: 1. Identification of a Neuroprotective and Selective Butyrylcholinesterase Inhibitor Derived from the Natural Alkaloid Evodiamine Guozheng Huang, Beata Kling, Fouad H. Darras, Jörg Heilmann and Michael Decker*, Eur. J. Med. Chem. 2014, 81 (0), 15-21. (The manuscript is attached) 2. Synthesis and Biological Evaluation of Bivalent Cannabinoid Receptor Ligands based on hCB2R selective Benzimidazoles Reveal Unexpected Intrinsic Properties Martin Nimczick, Daniela Pemp, Fouad H. Darras, Xinyu Chen, Jörg Heilmann and Michael Decker*, Bioorg. Med. Chem. 2014, 22 (25), 3938-3946.(The manuscript is attached) I had a master’s degree in organic chemistry from the Hashemite University – Jordan in 2006; my master’s work is published in the Journal of Heterocycles. (The manuscript is attached). I got my Bachelor degree in Chemistry from Mansura University – Egypt in 2001. (My CV is attached) Currently, I am working as a researcher at the research and innovation center (RIC) at the Jordanian Pharmaceutical Manufacturing Co. JPM in Amman-Jordan since 15th April 2014. I am really very interested to work under your supervision at your laboratory as post doc. I noticed that you are interested in developing, designing and synthesizing novel bio-active small molecules for the treatment of Neurodegenerative Diseases. I synthesized and identified more than 100 novel bio-active compound during my PhD study for different biological targets. I synthesized and biological evaluate a nomber of ChE Inhibitors (specifically anti butyrylcholinesterases), neuroprotective molecules, and hH3 antagonist ligands, and I have a very good experience in the neuroprotective neurotoxicity (cell based and chemical based assay) and a very good experience in drug design and structure activity relation ships SARs for anti-cholinesterases (MTDL) multi target direct ligand.