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Holodiag offer service "Crystallization processes"

Basic Information

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Trade Type

Offer Service

Service Name

Crystallization processes

Service Provider(s)

Specifications

  • Study Type: Crystallization process development covering polymorphism screening, solubility studies and phase-diagram characterization
  • Regulatory Compliance: Studies conducted under GLP-aligned laboratory procedures to support regulatory filing documentation
  • Therapeutic Area Expertise: Broadly applicable to small-molecule API programs across therapeutic areas, including enantiomer separation projects

Other Information

Additional Description:

This service builds the technical knowledge base needed for crystallization process development, covering polymorphism, solubility and phase-diagram studies. Applications span product recovery, yield and purity optimization, polymorphism control, enantiomer separation, converting oils into crystalline powders, particle engineering, filtration performance (cake resistance and compressibility) and drying to target residual solvent levels. Processes are designed with scale-up in mind, avoiding fast cooling and using industrially viable solvents, and matched to the client's plant capabilities such as cooling and filtration systems. Critical process parameters are identified and studied to establish robust operating conditions, with PhD-level crystallization specialists handling development from scratch as well as optimization and troubleshooting of existing processes.
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