Associate Professor

I am an instrumentation physicist and an associate professor at Université Paris Saclay. My research is about instrumentation and methods for preclinical and clinical imaging. During my Ph-D at Institut de Physique Nucléaire in Orsay (IPNO, France) and in the following years (1998-2006), I have developped the beta -Microprobe an instrument based on the limited range of beta particles within biologicla tissues. It allowed the detection with a high spatio-temporal resolution and in vivo of radiolabled tracers. It was validated and extensievly used for in situ measurement in rodents brain of pharmacokinetics of tracers of the dopaminergic and serotoninergic systems labeled with beta-emitters such as 18F-FDG or 11C-Raclopride. After a year as an assistant professor (ATER) , I got a permanent position as associate professor in 2002 in Université Paris -Sud and joined the Physics Biology Interface (IPB) Group in IPNO, where I developped several methodologies for radioimaging, including beta probe combination with MRI and in situ measurement of radiotracer input function (an important parameter for compartmental modelling of tracer uptake) without blood sampling. The IPB group grew with the recruitment of new modelization-specialists and neurophysiologists members and decided to create an independant laboratory "Imagerie et Modélisation en Neurobiologie et Cancérologie" in 2006. Simultaneously, and following fruitful interactions with these new colleagues, my research interests shifted to optical functional imaging of the rat and mice brain and more precisely to study the neurovascular coupling. In close collaboration with H Gurden and C Martin, I have developped several imaging set-ups and methods including intrinsic optical imaging (oxymetry mapping), autofluorescence imaging (mitochondrial activity mapping), tissue optical properties measurements, photon transport simulations in tissues and laser speckle imaging (microvascularization and blood flow mapping). I have been the scientific leader of the in vivo Biophotonics team in IMNC from 2012 to 2020. Following labs re-organization in University Paris Saclay, I moved in 2020 to the Biophotonics group in Laboratoire Charles Fabry (Institut Optique , Université Paris Saclay, Palaiseau) . The lab is oriented toward engineering and technological research in optics. I currently focus on new methodological approaches for multiple exposure laser speckle imaging for preclinical (mice obesity models) and clinical (skin microcirculation imaging) applications