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Postdoctoral Scholar

Jinsu Bae

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Postdoctoral ScholarVị trí mong muốn
Thứ 2 - Thứ 6Ngày có thể làm việc

Tóm tắt chuyên môn

Medicinal chemist and translational drug discovery scientist with end-to-end experience advancing novel small-molecule scaffolds from early discovery to preclinical candidates. At UCSF, I develop covalent inhibitors targeting oncogenic Gαq/11 signaling in uveal melanoma, using an integrated design–make–test–analyze (DMTA) workflow that connects structure-guided design, practical synthesis, and rigorous biological evaluation. Previously at GIST, I led programs on; (i) P2X3R antagonists for neuropathic pain as a non-opioid analgesics, and (ii) TG2–p53 pathway inhibitors for renal cell carcinoma, resulting in peer-reviewed publications, secured intellectual property, and successful technology transfer to industry. I also actively engage in scientific communication, including lectures on foundational AI/ML concepts for wet-lab scientists, scientific presentations, grant and manuscript writing, and mentoring graduate students. My skill set spans medicinal chemistry works and structure-guided drug design, complemented by chemical biology approaches, including biochemical, biophysical, and cell-based assays. My expertise focuses on the discovery, design, and development of small molecules based on the biological targets of disease mechanisms.

Kỹ năng

Medicinal Chemistry
Drug Discovery
Drug development
High-Throughput Screening
biophysical assays
biochemical assays
In vitro assays
Pharmacokinetics
Pharmacodynamics
covalent inhibitors
anti nociceptive agents
neuropathic pain
chronic pain
Gaq
GPCR
Uveal Melanoma
TG2 inhibitors
Prostate Cancer
Organic chemistry
multi step synthesis
hit identification
Hit-to-Lead Optimization
structure activity relationship study
structure guided drug design
Molecular Docking
cryoem
Structure based Drug Design
fragment based drug development
purinergic receptors

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