10-Hydroxycamptothecin

10-Hydroxycamptothecin (10-HCPT, CAS 19685-09-7/64439-81-2, C20H16N2O5) is an industrial-grade alkaloid derived from Camptotheca acuminata and a key intermediate in synthesizing irinotecan and topotecan. As a topoisomerase I inhibitor, it has shown activity against colorectal, lung, and ovarian cancers and leukemia; it appears as a yellow crystalline powder with limited water solubility but better solubility in DMSO, and its stability is pH-dependent, degrading under alkaline conditions. Manufactured directly by Hangzhou Lucky Biology Co., Ltd, it should be handled as a cytotoxic compound and stored cool, dry, and away from light; it is sold into Central/South America, Western Europe, Eastern Europe, Asia, and the Middle East.