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Principal Investigator

Ken Yoshioka

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周一 - 周五可工作日

专业摘要

I am a pharmaceutical scientist working at the interface of physicochemical analysis and pharmaceutical development, with a particular focus on surface free energy and interfacial phenomena in solid materials. My research centers on the characterization and interpretation of physicochemical properties of drug substances and powders, with an emphasis on inverse gas chromatography (IGC) as a tool for understanding surface energetics. With extensive experience in Chemistry, Manufacturing and Controls (CMC), quality control, and GMP-related activities, I am interested in bridging fundamental physicochemical principles with practical decision-making in pharmaceutical development and regulatory science. My work aims to provide physically interpretable frameworks that support the evaluation of material properties under conditions where experimental data may be limited or context-dependent. More recently, I have focused on structure-derived approaches to understanding drug absorption phenomena, particularly membrane permeability. By reorganizing commonly used physicochemical descriptors into unified representations, I seek to clarify relationships that are not readily captured by conventional metrics. My broader goal is to contribute to the development of transparent, conceptually grounded methodologies that complement existing experimental and computational approaches in drug discovery and pharmaceutical sciences.

技能

Surface Free Energy
Inverse Gas Chromatography (IGC)
Interfacial Interaction
Regulatory Science
CMC Development
Pharmaceutical materials science
Structure–Property Relationships

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