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Nicolas P F BARTHES

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About Member

Bio

As an organic chemist, I am interested in the design and synthesis of innovative compounds for pharmaceutical/agrochemical applications. These chemicals can be either tools (like fluorescent probes) beneficial to understand biological mechanisms or active substances exhibiting activities against major diseases (e.g. cancers) or parasites (e.g. pests). My courses and my positions in many multidisciplinary environments let me mature as a Drug Discovery Chemist. My thesis in the group of Prof. Dr. Alain Burger (UMR 7272 - France) was in direct connection with the precise aspect of chemical biology; that is the synthesis of fluorescent probes to study biological mechanisms as DNA methylation or HIV reverse transcription. This work was concluded by 14 publications, among which a J. Am. Chem. Soc., and a J. Org. Chem. In brief, the years I have spent in this domain not only enriched my scientific skills but also enhanced my personal and communication potentials. Subsequently, I have moved from my rich experience in the development of chemical tools/probes further on to Epigenetic Drug Discovery by joining the group of Prof. Dr. Manfred Jung (UniFreiburg - Germany) where I was working mainly on the design and synthesis of inhibitors of lysine methyltransferases and demethylases. My work on the KMD4A Demethylase has led to a publication in ACS. Chem. Biol. and another one is is in the course of submission. From my work on the synthesis of inhibitors of the novel KMT9 methyltransferase, I am co-inventor on a patent application that was submitted in September 2019.

Education

  • Institut de Chimie de Nice
    Degree Ph.D Student in the Synthesis and characterization of fluorescent probes and incorporation into DNA
    Field of Study Bioactive Molecules team - Chemistry
    Start Date 01/2012
    End Date 01/2015
    Description Ph.D Student in the Synthesis and characterization of fluorescent probes and incorporation into DNA oligonucleotides to study DNA methylation mechanism involving UHRF1 and DNMT1
  • Université Nice Sophia Antipolis - UFR Sciences
    Degree Ph.D Studies in Organic Chemistry
    Field of Study Chemistry
    Start Date 01/2012
    End Date 01/2015
  • Université Paul Sabatier
    Degree Master of Science (M.Sc.)
    Field of Study Medicinal Chemistry
    Start Date 01/2011
    End Date 01/2012
  • Université Paul Sabatier
    Degree Master of Science (M.Sc.)
    Field of Study Organic Chemistry & Biological Chemistry
    Start Date 01/2010
    End Date 01/2011
  • Université Paris-Sud XI
    Degree Bachelor of Science (B.Sc.)
    Field of Study Organic & Bioorganic Chemistry
    Start Date 01/2009
    End Date 01/2010

Experience

SA

Research Chemist

SpiroChem AG •

01/2020 – 01/2022 •

AF

Albert-Ludwigs-Universität Freiburg •

01/2016 – 01/2020 •

Institut für Pharmazeutische Wissenschaften

ID

Institut de Chimie de Nice •

01/2015 – 01/2016 •

Bioactive Molecules team - Chemistry

BC

Bayer CropScience •

01/2009 – 01/2010 •

Discovery

I'

Higher National Diploma (HND) in Chemistry

IUT 'A' Paul Sabatier •

01/2007 – 01/2009 •

Chemistry

SA

HND Intern in Solid Phase Peptide Synthesis (SPPS) of therapeutic cyclodepsipeptides

Sanofi Aventis •

01/2009 – 01/2009 •

Research